The hierarchy of nutrition levers during GLP-1 loss
- Total calories — still the #1 determinant of weight change.
- Protein — the #1 determinant of lean-mass preservation.
- Fiber — satiety, glucose, GI health.
- Fat type — inflammation, hormone production.
- Carb type — glucose curve, satiety.
- Meal timing — least important, patient-preference-driven.
Starting macro targets for common body sizes
Assuming ~20% caloric deficit from maintenance, moderate training:
- 140-lb goal (63 kg) → ~1,400 kcal: 95 g protein / 55 g fat / 120 g carbs.
- 160-lb goal (73 kg) → ~1,600 kcal: 110 g protein / 60 g fat / 140 g carbs.
- 180-lb goal (82 kg) → ~1,750 kcal: 120 g protein / 70 g fat / 150 g carbs.
- 200-lb goal (91 kg) → ~1,900 kcal: 130 g protein / 75 g fat / 170 g carbs.
- 220-lb goal (100 kg) → ~2,100 kcal: 145 g protein / 80 g fat / 190 g carbs.
How to flex macros for different situations
- Heavy training day: +30–50 g carbs pre/post workout.
- Insulin-resistant or PCOS: Drop carbs 20–30 g, raise fat a bit.
- Injection day (low appetite): Protein shake + fruit + nuts; don’t force dinner if not hungry.
- Plateau breaking: Hold protein steady; trim 100–200 kcal from carbs or fat.
- Maintenance: Expand calories 15–25%, keep protein grams stable.
Simple meal templates
Breakfast (~30 g protein): Greek yogurt + protein powder + berries + nuts. Or 3 egg whites + 2 whole eggs + spinach + avocado.
Lunch (~35 g protein): Large salad with 5 oz grilled protein + chickpeas + olive oil. Or lettuce wrap with turkey + hummus + vegetables.
Dinner (~30 g protein): 5 oz salmon or chicken + roasted vegetables + small portion of rice or sweet potato.
Snack (~15 g protein): Cottage cheese + fruit, protein bar, or a shake.